Chromosome changes in Alzheimer's presenile dementia.

Alzheimer's disease in one monozygotic twin.

A woman of 64 died after an illness lasting 15 years and characterized by a progressive amnesic syndrome followed by global dementia. The brain showed changes typical of Alzheimer's disease. Her monozygotic twin sister was clinically not affected and died two years later of carcinoma. This is the second report of monozygotic twin sisters apparently discordant for presenile dementia of Alzheimer...

Introducing Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring, an open access journal of the Alzheimer's Association

Syndrome of the month Nasu-Hakola syndrome: polycystic lipomembranous

Presenile dementia of genetic origin is often attributed to Alzheimer's disease. This disorder remains by far the commonest cause of early dementia. Pick disease and prion protein disorders are usually discussed in the differential diagnosis. We review here Nasu-Hakola syndrome (OMIM 221770), another unusual cause of presenile intellectual deterioration, in which neurological impairment occurs ...

Alzheimer's & Dementia: the Journal of the Alzheimer's Association.

Death certification after a diagnosis of presenile dementia.

STUDY OBJECTIVES To assess the value of death certification for the epidemiological study of dementia, the frequency with which the condition was recorded on death certificates of patients diagnosed with some form of dementia before the age of 65 years was studied. A further objective was to identify variables associated with failure to record dementia on the certificate. DESIGN A cohort of p...